Introduction to Systems Biology - Icahn School of Medicine at Mount SinaiCoursera
Was lernen Sie in diesem Kurs?
This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.Online learning plays a key role in lifelong learning. In fact, a recent report by the United States Department of Education found that "the courses that include online education (either completely virtual or blended learning) produce, on average, much stronger learning outcomes for students courses They are conducted exclusively in person. Based on an approach developed by educational psychologist Benjamin Bloom, the mastery learning helps students to fully understand a subject before moving on to a more advanced. In Coursera, usually we give an answer immediately to the concepts that the student does not understand feedback. In many cases, we offer random versions of assessments for the student to return to school and retrying until mastered the concept.